#Function of dendrite code#
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The code used to generate the results in this paper is available on. Received: NovemAccepted: MaPublished: April 10, 2023Ĭopyright: © 2023 Tang et al. Our results suggest that the functional role of NMDA is highly interplayed with the local properties of neuronal dendrites.Ĭitation: Tang Y, Zhang X, An L, Yu Z, Liu JK (2023) Diverse role of NMDA receptors for dendritic integration of neural dynamics. By exploring the role of NMDA at different parts of dendritic branches and regions, we found somatic responses are diverse from simple to complex spikes, depending on specific dendritic branches. Here we use Purkinje cell as a model system to symmetrically investigate this question, as the Purkinje cell exhibits a mixture of simple and complex spikes. However, it remains unclear how dendritic integration is related to the distribution of NMDA receptors on various parts of the dendritic morphology of a neuron. It has been documented that NMDA plays an important role in dendritic integration. Such a principle has been formulated as a question of dendritic integration, which depends on the biophysical properties of neuronal dendrites and their associated synapses. A fundamental principle for neural dynamics is how these inputs are collectively integrated and converged to the neuronal soma to generate diverse patterns of action potentials. Given the complexity of neural morphology varying in cell types, our work suggests that the functional role of NMDARs is not stereotyped but highly interwoven with local properties of neuronal structure.Ī single neuron receives a large number of inputs from its dendrites. Taken together, these results suggest that NMDARs play an important role in controlling excitability sensitivity while taking into account the factor of dendritic properties.
Detailed examination of the dendrites regarding their diameters and distance to soma revealed diverse response patterns, yet explain two firing modes, simple and complex spike. We found somatic responses can switch from silent, to simple spikes and complex spikes, depending on specific dendritic branches.
#Function of dendrite Pc#
Utilizing a computational PC model with detailed dendritic morphology, we explored the role of NMDARs at different parts of dendritic branches and regions. Although NMDARs are widely expressed in most types of neurons, they play a different role in the cerebellar Purkinje cells (PCs). NMDA receptors (NMDARs) are expressed as excitatory units, and play a key physiological role in synaptic function. Different types of synaptic receptors distributed over dendrites are responsible for receiving inputs from other neurons. Neurons, represented as a tree structure of morphology, have various distinguished branches of dendrites.
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